• Based on our findings in this

  2024-01-31

  

  Based on our findings in this work as well as the previous published data in the experimental mice model of RSV infection, we suggest that modulation of 12/15 LOX expression and/or blocking of LOX products such as 12(S)-HETE may represent potential pharmacological approaches to prevent or treat vira

• These mutations induce the gene

  2024-01-31

  

  These mutations induce the gene auto-activation in 10–40% of adenocarcinomas, triggering the EGFR-signaling pathway in the absence of ligand. That leads to an uncontrolled acceleration of cell proliferation, survival and anti-apoptotic signals (Couraud et al., 2012). The frequency of these mutations

• Using constant potential amperometry and electrochemical

  2024-01-30

  

  Using constant potential amperometry and electrochemical enzyme-based biosensors selective for choline—and, therefore, an accurate readout of USA release (Baker et al., 2015; Bruno et al., 2006a; Parikh et al., 2004, 2007)—tonic and phasic release of acetylcholine were measured simultaneously in th

• It has been known that LOX

  2024-01-30

  

  It has been known that 5-LOX is the rate-limiting enzyme for the products of LTs, and LTs actively participate in the activation of neutrophils [10]. In our study, we determined whether 5-LOX was upregulated in pancreatic tissues during ANP. Moreover, we investigated whether the inhibition of expres

• Protein protein interaction networks are an important ingred

  2024-01-30

  

  Protein–protein interaction networks are an important ingredient for the system-level understanding of cellular processes. Such networks can be used for filtering and assessing functional genomics data and for providing an instinctive platform for annotating structural, functional and evolutionary p

• SJB2-043 In clinical studies BA has been reported to promote

  2024-01-30

  

  In clinical studies, BA has been reported to promote dose-dependent LDL-C lowering effects of up to 30% as monotherapy, and up to an additional 24% when added in combination with stable statin therapy, or approximately 50% when combined with ezetimibe 109, 110, 111, 112. These effects were accompani

• In order to further explore whether

  2024-01-30

  

  In order to further explore whether the cytoprotective effect of isogarcinol against oxidative stress in H2O2-induced HepG2 cudc is a consequence of the breakdown of the endogenous antioxidant defence mechanism, we measured the LDH release, MDA levels, GSH levels and SOD activity. A large body of e

• c-met inhibitor HMGN proteins are subject to extensive post

  2024-01-30

  

  HMGN proteins are subject to extensive post-translational modifications which influence both their mode of binding to c-met inhibitor and their functional activity. Like the other HMG protein families, HMGNs are substrates for many of the same enzymes that modify histone proteins (review in [175]).

• According to the phytochemical screening Lophira procera is

  2024-01-30

  

  According to the phytochemical screening, Lophira procera is rich in phenolic compounds including total polyphenols, total flavonoids, tannins and proantocianidins. It has been reported that there is a correlation between total polyphenol content and antioxidant activity [29]. The present invention

• Pathological angiogenesis occurs when an imbalance

  2024-01-30

  

  Pathological angiogenesis occurs when an imbalance of endogenous proangiogenic and antiangiogenic factors occurs. Although the focus of angiogenesis-related drug development has been geared to the discovery of antiangiogenic compounds for use in pathologies where excessive angiogenesis occurs (cance

• br AR signaling and urothelial

  2024-01-30

  

  AR signaling and urothelial cancer progression As shown in other types of malignancies, such as prostate cancer cells, it has been documented that androgens induce AR expression and its nuclear translocation as well as ARE promoter activity in urothelial cancer cells (Chen et al., 2003, Izumi et 

• Asparagine synthetase ASNS is a

  2024-01-30

  

  Asparagine synthetase (ASNS) is a glutamine amidotransferase that catalyzes ATP-dependent synthesis of asparagine and glutamate from aspartate and glutamine. Upregulation of ASNS expression renders leukemia cells resistant to l-asparaginase treatment, and ASNS is essential for cell survival in the a

• br Discussion To our knowledge this is the first case

  2024-01-30

  

  Discussion To our knowledge, this is the first case report that demonstrates the presence of a novel T1151K ALK mutation in a patient with disease progression after crizotinib and then ceritinib. As early as 2011, Zhang et al. identified T1151K among other resistance mutations to crizotinib in Ba

• All desired compounds with a carboxylic acid substituent at

  2024-01-30

  

  All desired compounds with a carboxylic CAY10499 substituent at N1 position of the quinoxalinone scaffold and a variety of aromatic substituents at C3 position were obtained by the syntheses starting from methoxy-substituted 3-chloro-quinoxalin-2(1)-ones () prepared as previously. As shown in , comp

• br Conflict of interest br Acknowledgements We would

  2024-01-29

  

  Conflict of interest Acknowledgements We would like to thank Editage (www.editage.jp) for English language editing. This work was supported by Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant Number 24592576. Co-existence of β- and β-adrenergic recept

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