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The effect of the simple dopaminergic
2021-04-27
The effect of the simple dopaminergic tonic/phasic model on cognitive processing has been investigated by a few studies (Nolan et al., 2004; Rosa et al., 2010). Rosa et al. (2010), using a Stroop task that requires different levels of cognitive flexibility and stability, observed an association betw
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Meanwhile high levels of extraversion have been associated w
2021-04-27
Meanwhile, high levels of extraversion have been associated with weaker conditioning and faster SC 560 learning (Eysenck, 1970). Similar to neuroticism/anxiety, the role of extraversion for fear conditioning and extinction has found only limited empirical support (Rauch et al., 2005) with several s
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It is now known that cholinergic signaling
2021-04-27
It is now known that cholinergic signaling plays a vital role in controlling many peripheral functions including skeletal and smooth muscle contraction, autonomic postganglionic neuron activation, parasympathetic end-organ activation (e.g., salivary, lacrimal and bronchial glands), regulation of car
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ACE also known as Kininase II is an
2021-04-27
ACE also known as Kininase II is an important enzyme of the Renin angiotensin BCECF-AM australia system (RAAS) (Novo et al., 1987), it is believed to be a potent blood pressure regulator and also plays a crucial role in activation of the bradykinin receptor via inactivation of bradykinin which work
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br Results br Discussion Mucosal
2021-04-27
Results Discussion Mucosal barriers are constitutively challenged by various stimuli, and the homeostasis of mucosal barriers both at steady state and upon challenge are maintained by tissue-resident immune Methoxy-X04 (Kurashima et al., 2013, Okumura and Takeda, 2016). ILC3s are found in lymp
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br Conflicts of interest br Financial support
2021-04-27
Conflicts of interest Financial support NZ is an Established Investigator of the Dutch Heart Foundation (2013T111) and is supported by an ERC Consolidator grant (617376) from the European Research Council and by a Vici grant from the Netherlands Organization for Scientific Research (NWO; 91818
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Currently two approaches can be used individually or
2021-04-27
Currently, two approaches can be used individually or combinedly to overcome weak immunogenicity of subunit ap4 (Bookstaver et al., 2018; Moyle, 2017; Vartak and Sucheck, 2016). The first is to design particulate antigens. Virus-like particles (VLPs), for example—mainly derived from the capsid prot
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All components of the UPP were predicted
2021-04-26
All components of the UPP were predicted to be susceptible to oxidative stress due to the cysteine residues in their active sites [36]. Curcusone D inhibits DUBs but has no significant effect on the action of E1, E2s, E3s, or the proteasome, which indicates that the targets of the ROS induced by cur
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To determine whether the same concentration of humic
2021-04-26
To determine whether the same concentration of humic Angiotensin I (human, mouse, rat) receptor causes changes in PCR efficiency, we performed another experiment in which the humic acid was added to the PCR mix after bisulfite conversion. All samples that were amplified in the presence of humic acid
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br Experimental procedures br Introduction
2021-04-26
Experimental procedures Introduction Protein kinases represent one of the largest enzyme 69 0 in the human genome and act as signaling mediators in a variety of cellular processes (Manning et al., 2002). Because many diseases are associated with aberrant protein kinase activity, targeted kina
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Similarly LTD concentration dependently enhanced AQP express
2021-04-26
Similarly, LTD4 concentration-dependently enhanced AQP4 expression in astrocytes (Fig. 3). The LTD4-enhanced AQP4 expression was not affected by pranlukast but inhibited by Bay u9773, a non-selective CysLT1/CysLT2 receptor antagonist [33]. Because no selective CysLT2 receptor antagonists are current
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Natural and synthetic glucocorticoids perform their biologic
2021-04-26
Natural and synthetic glucocorticoids perform their biological action in the organism through receptor-dependent mechanisms (e.g., by binding to the glucocorticoid receptors). It has been determined that glucocorticoid receptors cross-talk with other nuclear receptors, including AhR (Celander et al.
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In humans CYP A major isoforms of CYP
2021-04-26
In humans, CYP3A4/5, major isoforms of CYP3As in the liver, have variants that reduce the enzyme activities [33], [34]. In addition, Werk et al. recently reported the first case of a complete failure of CYP3A enzyme activity due to homozygous loss-of-function mutation of CYP3A4 combined with nonfunc
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RG7388 Among prostaglandins PG PGD remained the
2021-04-26
Among prostaglandins (PG), PGD2 remained the most elusive species for a long time and was initially regarded as having negligible biological activity [1]. In 1974 its inhibitory effect on platelet aggregation was discovered by Smith et al. [2] and Mills & McFarlain [3], and both pressor and depresso
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br Diseases which have been treated with proteins linked
2021-04-26
Diseases which have been treated with proteins linked to HSA A number of therapeutic products conjugated to HSA have now been approved for clinical use (Table 2). For example, fatty pyruvate dehydrogenase kinase inhibitor derivatives of human insulin bound to HSA have applications in the treatme
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